Is the Honda Odyssey still better than the Toyota Sienna?

Not universally. In 2025, the Toyota Sienna is the better pick for most buyers who care about efficiency, while the Honda Odyssey can still be the better pick if you prioritize a more traditional gas-minivan feel and interior flexibility.

Where the Toyota Sienna is better

• Fuel economy: The 2025 Sienna is EPA-estimated at 36 mpg combined, compared with the 2025 Odyssey at 22 mpg combined.
• Lower fuel costs over time: That mpg gap is big enough that the Sienna will usually be the smarter choice for high-mileage families.

Where the Honda Odyssey may still be better

• More conventional driving feel: If you prefer a non-hybrid minivan with a stronger traditional V6 feel, the Odyssey may be more appealing.
• Family-use practicality: The Odyssey is still known for strong cabin flexibility and family-friendly packaging.

Bottom line

If you mean “better overall”, the Sienna usually has the edge today because of its much better fuel economy. If you mean “better to drive and live with” for your specific needs, the Odyssey can still be the better choice.